个人简介
王英,理学博士,暨南大学教授、博士生导师,广东省中药药效物质基础与创新药物研究重点实验室副主任。国家优秀青年科学基金获得者、教育部新世纪人才。1999年毕业于中国药科大学中药学院中药制剂专业,2003、2006年分别在同校获药物化学专业硕士和博士学位。2006年起,进入暨南大学药学院工作,先后任博士后、副教授、教授职位。
一直围绕中药及天然药物的活性成分开展研究工作。近年来,已先后对一叶萩、水翁、番石榴等40余种中药及天然药物开展了比较系统的活性成分研究。共分离鉴定了1500余种天然化合物,其中新化合物800余种(包括具新颖骨架结构的天然产物30余类),并发现了多个具显著抗病毒、治疗神经系统疾病等活性的天然化合物。已在Chem、Angew Chem Int Ed、Org Lett、 J Nat Prod等天然药物化学领域国际权威期刊发表SCI收录论文160余篇;主持国家自然科学基金优秀青年科学基金、科技部重点研发项目课题、“十三五”国家重大新药创制专项、国家自然科学基金面上及青年基金项目、广东省区域联合基金重点项目等科研和人才基金项目多项;已申请中国发明专利36项(获授权27项)、PCT专利3项;获国家科学技术进步奖二等奖1项、广东省科学技术奖一等奖3项。
研究方向
1.中药及天然药物活性成分研究
2.天然产物来源的创新药物发现研究
代表性论文
1.Song JG, Zheng J, Wei RJ, Huang YL, Jiang J, Ning GH, Wang Y*, Lu W*, Ye WC*, Li D*. Crystalline mate for structure elucidation of organic molecules. Chem, 2024, 10(3): 924-937. (IF: 23.5)
2.Wang J, Song JG, Zhong DL, Duan ZZ, Peng ZJ, Tang W, Song QY, Huang XJ, Hu LJ*, Wang Y*, Ye WC*. Biomimetic synthesis of an antiviral cinnamoylphloroglucinol collection from Cleistocalyxoperculatus: a synthetic strategy based on biogenetic building blocks. Angewandte Chemie-International Edition, 2023, 62(50), e202312568. (IF: 16.6)
3.He QF, Wu ZL, Li L, Sun WY, Wang GY, Jiang RW, Hu LJ, Shi L, He RR, Wang Y*, Ye WC*. Discovery of neuritogenic Securinega alkaloids from Flueggea suffruticosa by a building-block-based molecular network strategy. Angewandte Chemie-International Edition, 2021, 60: 19609. (IF: 16.6)
4.Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. AngewandteChemie, International Edition, 2014, 53: 5796−5799. (IF: 16.6)
5.Wu ZL, Zhang WY, Zhong JC, Huang XJ, Xu W, Chen MF, Weng SQ, Zhang DM, Che CT*, Ye WC*, Wang Y*. Angiogenesis-inhibitory piperidine alkaloids from the leaves of Microcos paniculata,Journal of Natural Products, 2022, 85: 375–383. (IF: 5.1)
6.Deng LM, Tang W, Wang SQ, Song JG, Huang XJ, Zhu HY, Li YL, Ye WC*, Hu LJ*, Wang Y*. Discovery and biomimetic synthesis of a polycyclic polymethylated phloroglucinol collection from Rhodomyrtus tomentosa, The Journal of Organic Chemistry, 2022, 87: 4788–4800. (IF: 3.6)
7.Deng LM, Hu LJ, Bai YTZ, Wang J, Qin GQ, Song QY, Su JC, Huang XJ, Jiang RW, Tang W, Li YL, Li CC*, Ye WC*, Wang Y*. Rhodomentosones A and B: two pairs of enantiomeric phloroglucinol trimers from Rhodomyrtus tomentosa and their asymmetric biomimetic synthesis, Organic Letters, 2021, 23: 4499–4504. (IF: 5.2)
8.Deng LM, Hu LJ, Tang W, Liu JX, Huang XJ, Li YY, Li YL, Ye WC*, Wang Y*. A biomimetic synthesis-enabled stereochemical assignment of rhodotomentones A and B, two unusual caryophyllene-derived meroterpenoids from Rhodomyrtus tomentosa, Organic Chemistry Frontiers, 2021, 8: 5728–5735. (IF: 5.4)
9.Luo SL, Hu LJ, Huang XJ, Su JC, Shao XH, Wang L, Xu HH, Li CC*, Wang Y*, Ye WC*. Discovery and biomimetic synthesis of a phloroglucinol-terpene adduct collection from Baeckea frutescens and its biogenetic origin insight, Chemistry-A European Journal, 2020, 26: 11104–11108. (IF: 4.3)
10.Song JG, Su JC, Song QY, Huang RL, Tang W, Hu LJ, Huang XJ, Jiang RW, Li YL, Ye WC*, Wang Y*. Cleistocaltones A and B, antiviral phloroglucinol-terpenoid adducts from Cleistocalyx operculatus, Organic Letters, 2019, 21: 9579–9583. (IF: 5.2)