个人简介

张君秋，博士，2016年6月毕业于中山大学生物技术基地班，获学士学位；2016年8月-2022年5月在美国德克萨斯大学西南医学中心（The university of Texas Southwestern Medical Center)攻读肿瘤学PhD，获博士学位；2022年10月至今，在暨南大学从事博士后研究工作。一直从事结直肠癌相关肿瘤发生发展进程、机制及克服策略研究，以唯一第一作者发表PNAS，参与的其他工作发表于Cancer cell、PNAS、JCI insight、Drug resistance updates等。参与美国研究生生物化学与分子生物学教材编写。

研究方向

1.DNA错配修复（MMR）与结直肠癌肿瘤免疫

2.结构生物学鉴定生物大分子相互作用及小分子作用位点

4.肿瘤新靶点与创新药物研究 

代表性论文

1.Junqiu Zhang ; Xin Zhao; Lu Liu; Hao-Dong Li; Liya Gu; Diego H. Castrillon; Guo-Min Li ;The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks, Proceedings of the National Academy of Sciences, 2022, 119(40):e2201738119 

2.Sun, Xiao, Lu Liu, Chao Wu, Xueying Li, Jinzhen Guo, Junqiu Zhang, Junhong Guan, Nan Wang, Liya Gu, X. Willian Yang, and Guo-Min Li. 'Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis', Proceedings of the National Academy of Sciences, 2024, 121: e2313652121.

3.Junhong Guan, Changzheng Lu, Qihuang Jin, Huiming Lu, Xiang Chen, Lei Tian, Yanbin Zhang, Janice Ortega, Junqiu Zhang, Silvia Siteni, Mingyi Chen, Liya Gu, Jerry W. Shay, Anthony J. Davis, Zhijian J. Chen, Yang-Xin Fu, Guo-Min Li, MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway, Cancer Cell, 2021, 39(1): 109-121.e5

4.Hao-Dong Li; Changzheng Lu; He Zhang; Qing Hu; Junqiu Zhang ; Ileana C. Cuevas; SubhransuS. Sahoo; Mitzi Aguilar; Elizabeth G. Maurais; Shanrong Zhang; Xiaojing Wang; Esra A. Akbay; GuoMin Li; Bo Li; Prasad Koduru; Peter Ly; Yang-Xin Fu; Diego H. Castrillon ; A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response, JCI insight, 2020, 5(14): e138829

5.Huocong Huang; Steven Wright; Junqiu Zhang; Rolf A.Brekken ; Getting a grip on adhesion: Cadherin switching and collagen signaling, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019, 1866(11): 118472

6.Qing Wen; Maohua Huang; Jingwen Xie; Runyu Liu; Qun Miao; Jinjun Huang; Junqiu Zhang ;Wenyu lyu; Ming Qi; Chunyi Wu; Qi Qi; Zhijing Zhang; Rong Deng; Chenran Wang; Zhe-Sheng Chen;Dongmei Zhang; Wencai Ye; Minfeng Chen ; lncRNA SYTL5-OT4 promotes vessel co-option by inhibitingthe autophagic degradation of ASCT2, Drug Resistance Updates, 2023, 69: 100975

7.Ye, G., Y. Jiao, L. Deng, M. Cheng, S. Wang, J. Zhang, J. Ouyang, Y. Li, Y. He, Z. Tu, Z. Wang, X. Song, C. Wang, Q. Qi, D. Zhang, L. Wang, M. Huang, W. Ye, and M. Chen. 'Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway', Int J Biol Sci,  2023.19: 4376-92.