个人简历

张世卿，副研究员，硕士生导师。2009年毕业于南方医科大学中药学专业，获学士学位；2012年毕业于南方医科大学中药药理学专业，获硕士学位； 2016年毕业于香港浸会大学神经生物学专业，获博士学位；2016年-2021年先后担任香港浸会大学博士后、研究助理教授；2021年起担任暨南大学药学院副研究员、硕士生导师。现兼任广东省药理学会中药药理专业委员会委员，广东省中医药学会中药实验药理专业委员会青年委员。

主要开展中药和天然药物来源的神经系统疾病药物发现，以及神经系统疾病的病理机制研究。以第一作者/通讯作者在Advanced Science、ACS Appl Mater Interfaces、Pharmacol Res、Acta Pharmacol Sin、J Ginseng Res、Phytomedicine等期刊发表SCI论文23篇。主持国家自然科学基金青年科学基金项目1项，广东省自然科学基金青年提升项目和面上项目各1项。获中国神经修复学年会青年论坛优胜奖，并入选第72届德国林道诺贝尔奖获得者大会。讲授药理学、制药生物技术等多门本科生和研究生课程。

研究方向

1.神经药理学及创新药物研发

代表性论文

1.Zhang SQ#, Sun P#, Lin K#, Chan FHL, Gao Q, Lau WF, Roy VAL, Zhang HQ, Lai KWC*, Huang ZF*, Yung KKL*. Extracellular nanomatrix-induced self-organization of neural stem cells into miniature substantia nigra-like structures with therapeutic effects on Parkinsonian rats. Advanced Science. 2019, 6(24): 1901822. (IF: 15.8)

2.Wu X#, Yi X#, Zhao B, Zhi Y, Xu Z, Cao Y, Cao X, Pang J, Yung KKL, Zhang S*, Liu S*, Zhou P*. The volume-regulated anion channel regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function. Pharmacological Research. 2023, 198, 107016. (IF: 9.3)

3.Wang Y#, Tan Z#, Zhang Z, Zhu P, Tam SW, Zhang Z, Jiang X, Lin K, Tian L, Huang Z, Zhang S*, Peng YK*, Yung KKL*. Facet-dependent activity of CeO2 nanozymes regulate the fate of human neural progenitor cell via redox homeostasis. ACS Applied Materials & Interfaces. 2022, 14(31): 35423-35433. (IF: 10.4)

4.Lin KL#, Sze SCW#, Liu B, Zhang Z, Zhang Z, Zhu PL, Wong Y, Deng QD, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis. Journal of Ginseng Research. 2021, 45: 325-333. (IF: 5.7)

5.Lin KL#, Liu B#, Lim SL, Fu XQ, Sze SCW, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol promotes the migration, proliferation and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway. Journal of Ginseng Research. 2020, 44: 475-482. (IF: 6.1)

6.Wu X Y#, Lv J Y#, Zhang SQ#, Yi X, Xu ZW, Zhi YX, Zhao BX, Pang JX, Yung K*, Liu SW*, Zhou PZ*. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacologica Sinica. 2022, 43(4): 992-1000. (IF: 7.2)

7.Lin K#, Zhang Z#, Zhang Z#, Zhu P, Jiang X, Wang Y, Deng Q*, Lam Yung KK*, Zhang S*. Oleanolic acid alleviates cerebral ischemia/reperfusion injury via regulation of the GSK-3β/HO-1 signaling pathway. Pharmaceuticals. 2021, 15(1): 1. (IF: 5.2) 

8.Jiang XL#, Deng B#, Deng SH#, Cai M, Tian ZB, Chen RX, Xu YC, Ding WJ, Xu HL, Zhang SW, Zhang SQ*, Liu B*, Zhang JZ*. Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src. Phytomedicine. 2022, 95:153705. (IF: 6.7) 

9.Zhang SQ#, Jiang XL#, Wang Y, Lin KL, Zhang Z, Zhang Z, Ng ML, Qu SG, Sze SCW*, Yung KKL*. Protective Effect of An-Gong-Niu-Huang Wan Pre-treatment against Experimental Cerebral Ischemia Injury via Regulating GSK-3β/HO-1 Pathway. Frontiers in Pharmacology. 2021, 16: 640297. (IF: 6.0)

10.Deng G#, Liu C#, Zhao J#, Wang M#, Li Y, Yang M, Ye H, Li J, Qin M, Wu C, Shi H, Liao Y, Zhou Z, Zhang S*, Lam Yung KK*, Lei G*. Exocarpium Citri Grandis alleviates the aggravation of NAFLD by mitigating lipid accumulation and iron metabolism disorders. Journal of Ethnopharmacology. 2023, 313:116559. (IF: 5.4)